Upcoming Event

"Mechanobiology and Biomarkers of Thoracic Aortic Aneurysm and Dissection"
Christopher Koch
Ph.D. Candidate
Cleveland State University
Department of Chemistry
Apte Lab
Friday, March 9, 2018

"Protein TAILS Tell Remarkable Tales:  Probing the N-terminome for Mechanistic Insight into Proteolytic Pathways in vivo"
Christopher M. Overall, Ph.D.
Canada Research Chair in Protease Proteomics and Systems Biology
Life Sciences Institute
University of British Columbia
Wednesday, March 14, 2018

Bone Strain Measurement During Simulation of Lower Extremity Musculoskeletal Biomechanics

Client: Peter Cavanagh Ph.D., D.Sc. and Brian Davis Ph.D. / Cleveland Clinic and NASA

Services Provided: Experiment Design / Robotic Foot Joint Testing / Data Analysis / Manuscript Preparation

Orthopedic research that investigates the in vitro forces applied to bones, tendons and ligaments during simulated exercise has been difficult to achieve due to limitations of applying full-physiological loading to the joint under investigation in a real-time manner. The Universal Musculoskeletal Simulator (UMS) allows researchers to simulate exercise on cadaver joints by using motorized actuators to simulate muscle forces and simultaneously contact the joint with an external load. This study simulated walking at one-fourth speed and varying BW percentages (16.5%, 38.4%, 66.7%, and 100% BW). Bone strain measurements were recorded for correlation with the extrinsic muscle forces and external forces during the exercise.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/20370251