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Upcoming Event

BME GUEST SPEAKER SEMINAR
"Interrogating Therapeutic Responses to Multiple Therapeutic Candidates in the Best Cancer Model Available: Humans"

James Olson, M.D., Ph.D.
Professor
University of Washington
Medical, Clinical Research Division
Fred Hutchinson Cancer Research Center
Hosted by Chris Hubert, Ph.D.
November 19, 2018




Bone Strain Measurement During Simulation of Lower Extremity Musculoskeletal Biomechanics

Client: Peter Cavanagh Ph.D., D.Sc. and Brian Davis Ph.D. / Cleveland Clinic and NASA

Services Provided: Experiment Design / Robotic Foot Joint Testing / Data Analysis / Manuscript Preparation

Orthopedic research that investigates the in vitro forces applied to bones, tendons and ligaments during simulated exercise has been difficult to achieve due to limitations of applying full-physiological loading to the joint under investigation in a real-time manner. The Universal Musculoskeletal Simulator (UMS) allows researchers to simulate exercise on cadaver joints by using motorized actuators to simulate muscle forces and simultaneously contact the joint with an external load. This study simulated walking at one-fourth speed and varying BW percentages (16.5%, 38.4%, 66.7%, and 100% BW). Bone strain measurements were recorded for correlation with the extrinsic muscle forces and external forces during the exercise.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/20370251