Upcoming Event

"Mechanobiology and Biomarkers of Thoracic Aortic Aneurysm and Dissection"
Christopher Koch
Ph.D. Candidate
Cleveland State University
Department of Chemistry
Apte Lab
Friday, March 9, 2018

"Protein TAILS Tell Remarkable Tales:  Probing the N-terminome for Mechanistic Insight into Proteolytic Pathways in vivo"
Christopher M. Overall, Ph.D.
Canada Research Chair in Protease Proteomics and Systems Biology
Life Sciences Institute
University of British Columbia
Wednesday, March 14, 2018

Effect of Humeral Head Defect Size on Glenohumeral Stability: A Cadaveric Study of Simulated Hill-Sachs Defects

Client:Scott Kaar M.D. and Steve Fening Ph.D. / Cleveland Clinic

Services Provided: Experiment Design / Robotic Shoulder Joint Testing / Data Analysis / Manuscript Preparation

Hill-Sachs lesions are often present with recurrent shoulder instability and may be a cause of failed Bankart repair. The goal of this study was to determine how large of a lesion is required to reduce stability. Humeral head defects, 1/8, 3/8, 5/8, and 7/8 of the humeral head radius, were created in 8 human cadaveric shoulders, simulating Hill-Sachs defects. Testing positions included 45 degrees and 90 degrees of abduction and 40 degrees of internal rotation, neutral, and 40 degrees of external rotation. Testing occurred at each defect size sequentially from smallest to largest for all abduction and rotation combinations. The humeral head was translated at 0.5 mm/s 45 degrees anteroinferiorly to the horizontal glenoid axis until dislocation. Distance to dislocation, defined as humeral head translation until it began to subluxate, was the primary outcome measure. The study found that glenohumeral stability decreases at a 5/8 radius defect in external rotation and abduction. At 7/8 radius, there was a further decrease in stability at neutral and external rotation.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/20194958