Upcoming Event

"Mechanobiology and Biomarkers of Thoracic Aortic Aneurysm and Dissection"
Christopher Koch
Ph.D. Candidate
Cleveland State University
Department of Chemistry
Apte Lab
Friday, March 9, 2018

"Protein TAILS Tell Remarkable Tales:  Probing the N-terminome for Mechanistic Insight into Proteolytic Pathways in vivo"
Christopher M. Overall, Ph.D.
Canada Research Chair in Protease Proteomics and Systems Biology
Life Sciences Institute
University of British Columbia
Wednesday, March 14, 2018


Client: Ahmet Erdemir Ph.D. / Cleveland Clinic

Services Provided: Experiment Design / Uniaxial Material Testing / Robotic Knee Joint Testing / Data Analysis

Cells of the musculoskeletal system are known to have a biological response to deformation. Deformations, when abnormal in magnitude, duration, and/or frequency content, can lead to cell damage and possible disruption in homeostasis of the extracellular matrix. These mechanisms can be studied in an isolated fashion but connecting mechanical cellular response to organ level mechanics and human movement requires a multiscale approach. The goal of this research program is to portray that prediction of cell deformations from loads acting on the human body, therefore a clear depiction of the mechanical pathway, is possible, if a multiscale simulation approach is used. Multiresolution models of the knee joint, representative of joint, tissue and cell structure and mechanics, were developed for this purpose. Comprehensive mechanical testing at joint, tissue and cell levels were conducted for parameter estimation and validation, including in vitro loading of the knee joint representative of lifelike loading scenarios. The research team will utilize this platform to establish the relationship between the structural and loading state of the knee and chondrocyte stresses to explore potential mechanisms of cartilage degeneration.