Portfolio

Upcoming Event

BME GUEST SPEAKER SEMINAR
"Interrogating Therapeutic Responses to Multiple Therapeutic Candidates in the Best Cancer Model Available: Humans"

James Olson, M.D., Ph.D.
Professor
University of Washington
Medical, Clinical Research Division
Fred Hutchinson Cancer Research Center
Hosted by Chris Hubert, Ph.D.
November 19, 2018




 

Client: Ahmet Erdemir Ph.D. / Cleveland Clinic

Services Provided: Experiment Design / Uniaxial Material Testing / Robotic Knee Joint Testing / Data Analysis

Cells of the musculoskeletal system are known to have a biological response to deformation. Deformations, when abnormal in magnitude, duration, and/or frequency content, can lead to cell damage and possible disruption in homeostasis of the extracellular matrix. These mechanisms can be studied in an isolated fashion but connecting mechanical cellular response to organ level mechanics and human movement requires a multiscale approach. The goal of this research program is to portray that prediction of cell deformations from loads acting on the human body, therefore a clear depiction of the mechanical pathway, is possible, if a multiscale simulation approach is used. Multiresolution models of the knee joint, representative of joint, tissue and cell structure and mechanics, were developed for this purpose. Comprehensive mechanical testing at joint, tissue and cell levels were conducted for parameter estimation and validation, including in vitro loading of the knee joint representative of lifelike loading scenarios. The research team will utilize this platform to establish the relationship between the structural and loading state of the knee and chondrocyte stresses to explore potential mechanisms of cartilage degeneration.