Portfolio

Upcoming Event

Johnson & Johnson Mechanical Testing and Analysis Summit 
Robb Colbrunn, Ph.D., Guest Speaker
Director of BioRobotics and Mechanical Testing Core
Medical Device Solutions (MDS) Cleveland Clinic
Adjunct Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
September 18-20, 2018
Syracuse, IN

BME GUEST SPEAKER SEMINAR
"Back to Metabolism Basics:Transport and Bioenergetics in Tumors and Brain Endothelial Cells"
Lester R. Drewes, Ph.D.
Professor of 
Biochemistry & Molecular Biology
Director, Graduate Programs, MSD
Department of Biomedical Sciences
University of Minnesota Medical School Duluth
Hosted by Chaitali Ghosh, PhD.
September 28, 2018



 

Client: Ahmet Erdemir Ph.D. / Cleveland Clinic

Services Provided: Experiment Design / Uniaxial Material Testing / Robotic Knee Joint Testing / Data Analysis

Cells of the musculoskeletal system are known to have a biological response to deformation. Deformations, when abnormal in magnitude, duration, and/or frequency content, can lead to cell damage and possible disruption in homeostasis of the extracellular matrix. These mechanisms can be studied in an isolated fashion but connecting mechanical cellular response to organ level mechanics and human movement requires a multiscale approach. The goal of this research program is to portray that prediction of cell deformations from loads acting on the human body, therefore a clear depiction of the mechanical pathway, is possible, if a multiscale simulation approach is used. Multiresolution models of the knee joint, representative of joint, tissue and cell structure and mechanics, were developed for this purpose. Comprehensive mechanical testing at joint, tissue and cell levels were conducted for parameter estimation and validation, including in vitro loading of the knee joint representative of lifelike loading scenarios. The research team will utilize this platform to establish the relationship between the structural and loading state of the knee and chondrocyte stresses to explore potential mechanisms of cartilage degeneration.