Upcoming Event

Johnson & Johnson Mechanical Testing and Analysis Summit 
Robb Colbrunn, Ph.D., Guest Speaker
Director of BioRobotics and Mechanical Testing Core
Medical Device Solutions (MDS) Cleveland Clinic
Adjunct Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
September 18-20, 2018
Syracuse, IN

"Back to Metabolism Basics:Transport and Bioenergetics in Tumors and Brain Endothelial Cells"
Lester R. Drewes, Ph.D.
Professor of 
Biochemistry & Molecular Biology
Director, Graduate Programs, MSD
Department of Biomedical Sciences
University of Minnesota Medical School Duluth
Hosted by Chaitali Ghosh, PhD.
September 28, 2018

Assessment of the Effects of Diabetes on Midfoot Joint Pressures

Client: Brian Davis Ph.D. / Cleveland Clinic

Services provided: Experiment Design / Robotic Foot Joint Testing / Data Analysis / Manuscript Preparation

One of the more serious diabetic complications is Charcot neuroarthropathy (CN), a disease that results in arch collapse and permanent foot deformity. However, very little is known about the etiology of CN. From a mechanical standpoint, it is likely that there is a “vicious circle” in terms of (i) arch collapse causing increased midfoot joint pressures, and (ii) increased joint contact pressures exacerbating the collapse of midfoot bones. This study focused on assessment of peak joint pressure difference between diabetic and non-diabetic cadaver feet during simulated walking. We hypothesized that joint pressures are higher for diabetics than normal population. Materials and Methods: Sixteen cadaver foot specimens (eight control and eight diabetic specimens) were used in this study. Human gait at 25% of typical walking speed (averaged stance duration of 3.2s) was simulated by a custom-designed Universal Musculoskeletal Simulator. Four medial midfoot joint pressures (the first metatarsocuneiform, the medial naviculocuneiform, the middle naviculocuneiform, and the first intercuneiform) were measured dynamically during full stance. Results: The pressures in each of the four measured midfoot joints were significantly greater in the diabetic feet (p = 0.015, p = 0.025, p < 0.001, and p = 0.545, respectively). Conclusion: Across all four tested joints, the diabetic cadaver specimens had, on average, 46% higher peak pressures than the control cadaver feet during the simulated stance phase. Clinical Relevance: This finding suggests that diabetic patients could be predisposed to arch collapse even before there are visible signs of bone or joint abnormalities.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/19735634