Portfolio

Upcoming Event

Johnson & Johnson Mechanical Testing and Analysis Summit 
Robb Colbrunn, Ph.D., Guest Speaker
Director of BioRobotics and Mechanical Testing Core
Medical Device Solutions (MDS) Cleveland Clinic
Adjunct Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
September 18-20, 2018
Syracuse, IN




Biomechanical Phenotyping with 3 Point Bending: ADAMTS molecules, fibrillin-1 networks and cell regulation

Client: Suneel Apte M.B.B.S, D.Phil. / Cleveland Clinic

Services Provided: Uniaxial Material Testing

Several ADAMTS family members, e.g., ADAMTS10, ADAMTS17, ADAMTSL4, and ADAMTSL2, are mutated in disorders associated with fibrillin-1, a critical component of an extracellular network that regulates TGF-beta. These human and animal mutations have highlighted the potential role of ADAMTS proteins in fibrillin-rich tissues such as the zonule of the eye, and in regulating skeletal growth and skin/organ fibrosis. The project utilized a 3 point bending method on murine femurs to assist the research program in understanding the contributions to overall bone strength.