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Upcoming Event

BME GUEST SEMINAR
"The 'Art' of Computational Modeling in Knee Biomechanics"
Ahmet Erdemir, PhD, Cleveland Clinic
Jason Halloran, PhD, Cleveland State University
Carl Imhauser, PhD, Hospital for Special Surgery
Peter Laz, PhD, University of Denver
Kevin Shelburne, PhD, University of Denver
Wednesday, December 13, 2017 

 

Biomechanical Phenotyping with 3 Point Bending: ADAMTS molecules, fibrillin-1 networks and cell regulation

Client: Suneel Apte M.B.B.S, D.Phil. / Cleveland Clinic

Services Provided: Uniaxial Material Testing

Several ADAMTS family members, e.g., ADAMTS10, ADAMTS17, ADAMTSL4, and ADAMTSL2, are mutated in disorders associated with fibrillin-1, a critical component of an extracellular network that regulates TGF-beta. These human and animal mutations have highlighted the potential role of ADAMTS proteins in fibrillin-rich tissues such as the zonule of the eye, and in regulating skeletal growth and skin/organ fibrosis. The project utilized a 3 point bending method on murine femurs to assist the research program in understanding the contributions to overall bone strength.