Portfolio

Upcoming Event

Cleveland Clinic
Department of Biomedical Engineering 
BME Guest Speaker
"Cerebrovascular Care in 2019 - Advances and Challenges"
M. Shazam Hussain, MD
Staff, Cerebrovascular Center
Cleveland Clinic
Friday, November 15, 2019
Hosted by: Vinod Labhasetwar, PhD

Biomechanical Phenotyping with 3 Point Bending: ADAMTS molecules, fibrillin-1 networks and cell regulation

Client: Suneel Apte M.B.B.S, D.Phil. / Cleveland Clinic

Services Provided: Uniaxial Material Testing

Several ADAMTS family members, e.g., ADAMTS10, ADAMTS17, ADAMTSL4, and ADAMTSL2, are mutated in disorders associated with fibrillin-1, a critical component of an extracellular network that regulates TGF-beta. These human and animal mutations have highlighted the potential role of ADAMTS proteins in fibrillin-rich tissues such as the zonule of the eye, and in regulating skeletal growth and skin/organ fibrosis. The project utilized a 3 point bending method on murine femurs to assist the research program in understanding the contributions to overall bone strength.