Portfolio

Upcoming Event

BME GUEST SPEAKER SEMINAR
"Interrogating Therapeutic Responses to Multiple Therapeutic Candidates in the Best Cancer Model Available: Humans"

James Olson, M.D., Ph.D.
Professor
University of Washington
Medical, Clinical Research Division
Fred Hutchinson Cancer Research Center
Hosted by Chris Hubert, Ph.D.
November 19, 2018




Biomechanical Phenotyping with 3 Point Bending: ADAMTS molecules, fibrillin-1 networks and cell regulation

Client: Suneel Apte M.B.B.S, D.Phil. / Cleveland Clinic

Services Provided: Uniaxial Material Testing

Several ADAMTS family members, e.g., ADAMTS10, ADAMTS17, ADAMTSL4, and ADAMTSL2, are mutated in disorders associated with fibrillin-1, a critical component of an extracellular network that regulates TGF-beta. These human and animal mutations have highlighted the potential role of ADAMTS proteins in fibrillin-rich tissues such as the zonule of the eye, and in regulating skeletal growth and skin/organ fibrosis. The project utilized a 3 point bending method on murine femurs to assist the research program in understanding the contributions to overall bone strength.