Portfolio

Upcoming Event

Cleveland Clinic
Department of Biomedical Engineering 
LRI Visiting Professor Seminar
"Coordinated Contributions of Genetics, Metabolism and Epigenetics in the Pathogenesis of Pulmonary Arterial Hypertension"
Marlene Rabinovitch, M.D.
Dwight and Vera Dunlevie Professor of Pediatrics, Cardiology
Stanford University 
Monday, October 14, 2019

Biomechanical Phenotyping with 3 Point Bending: ADAMTS molecules, fibrillin-1 networks and cell regulation

Client: Suneel Apte M.B.B.S, D.Phil. / Cleveland Clinic

Services Provided: Uniaxial Material Testing

Several ADAMTS family members, e.g., ADAMTS10, ADAMTS17, ADAMTSL4, and ADAMTSL2, are mutated in disorders associated with fibrillin-1, a critical component of an extracellular network that regulates TGF-beta. These human and animal mutations have highlighted the potential role of ADAMTS proteins in fibrillin-rich tissues such as the zonule of the eye, and in regulating skeletal growth and skin/organ fibrosis. The project utilized a 3 point bending method on murine femurs to assist the research program in understanding the contributions to overall bone strength.