Portfolio

Upcoming Event

Department of Biomedical Engineering
BME Guest Speaker
"Functional Consequences of Fibroblast Loss in Tissue Homeostasis and Disease"
Michelle Tallquist, Ph.D.
Professor and Chair
Cell and Molecular Biology Graduate Program
University of Hawaii
Friday, August 2, 2019
Hosted by: Suneel Apte, MBBS, DPhil









Biomechanical Phenotyping with 3 Point Bending: ADAMTS molecules, fibrillin-1 networks and cell regulation

Client: Suneel Apte M.B.B.S, D.Phil. / Cleveland Clinic

Services Provided: Uniaxial Material Testing

Several ADAMTS family members, e.g., ADAMTS10, ADAMTS17, ADAMTSL4, and ADAMTSL2, are mutated in disorders associated with fibrillin-1, a critical component of an extracellular network that regulates TGF-beta. These human and animal mutations have highlighted the potential role of ADAMTS proteins in fibrillin-rich tissues such as the zonule of the eye, and in regulating skeletal growth and skin/organ fibrosis. The project utilized a 3 point bending method on murine femurs to assist the research program in understanding the contributions to overall bone strength.