Portfolio

Upcoming Event

BME GUEST SPEAKER SEMINAR
"Wearable Sensors for Clinical Decision Support: Are We Watching the Clock?"

Colin K. Drummond, Ph.D., MBA
Professor and Assistant Chair
Department of Biomedical Engineering
Case Western Reserve University
January 11, 2019




Biomechanical Phenotyping with 3 Point Bending: ADAMTS molecules, fibrillin-1 networks and cell regulation

Client: Suneel Apte M.B.B.S, D.Phil. / Cleveland Clinic

Services Provided: Uniaxial Material Testing

Several ADAMTS family members, e.g., ADAMTS10, ADAMTS17, ADAMTSL4, and ADAMTSL2, are mutated in disorders associated with fibrillin-1, a critical component of an extracellular network that regulates TGF-beta. These human and animal mutations have highlighted the potential role of ADAMTS proteins in fibrillin-rich tissues such as the zonule of the eye, and in regulating skeletal growth and skin/organ fibrosis. The project utilized a 3 point bending method on murine femurs to assist the research program in understanding the contributions to overall bone strength.