Upcoming Event

"Mechanobiology and Biomarkers of Thoracic Aortic Aneurysm and Dissection"
Christopher Koch
Ph.D. Candidate
Cleveland State University
Department of Chemistry
Apte Lab
Friday, March 9, 2018

"Protein TAILS Tell Remarkable Tales:  Probing the N-terminome for Mechanistic Insight into Proteolytic Pathways in vivo"
Christopher M. Overall, Ph.D.
Canada Research Chair in Protease Proteomics and Systems Biology
Life Sciences Institute
University of British Columbia
Wednesday, March 14, 2018

Micro PET/SPECT Phantom Development

Client: Nuclear Imaging (Dr. Frank DiFilippo)

Services Provided: Mechanical Design, optimizing the usability of the device and manufacturing via Stereolithography | CAD Modeling in Pro/ENGINEER | Rapid Prototyping

Dr. DiFilippo approached MDS regarding support of a NIH grant. One of the grant aims was to develop an optimized set of calibration spheres (phantoms) for micro-PET and micro-SPECT nuclear imaging machines. The calibration spheres would need to be part of an assembly that could be rotated within an outer fixture as part of the improved imaging routine that was proposed in the grant.

MDS presented several design iterations to Dr. DiFilippo, each time further optimizing the design. Additionally, the parts were designed such that they could be built via stereolithography without any internal supporting structures. A clear, waterproof resin was chosen to build the parts. This resulted in parts that were very easy to visualize, which was important for the operators who were filled the internal sphere structures with a radioactive fluid.

Results have been published in the journal Physics in Medicine and Biology (Phys. Med. Biol. 55 (2010) 5363–5381)